Russian regions cannot and will never be the subject of any deals, presidential spokesman Dmitry Peskov said.
He commented on the words of Turkish university professor Maltepe Hasan Unal that Moscow and Ankara may agree on the status of Crimea if Russia recognizes the Turkish Republic of Northern Cyprus as an independent state.
The Kremlin spokesman ruled out the possibility of such agreements.
"It is unlikely that a respected professor from Turkey can personify Ankara's official viewpoint," he added.
Cyprus has been divided in two since 1974, when Turkey invaded it because of attempts by Greece to annex it. In 1983, the Turkish Republic of Northern Cyprus was proclaimed in the occupied territory of the island (37%) - only Turkey recognized it.
Negotiations between the Greek and Turkish sides are mediated by the UN, but they broke down after the failure of another round in Crans-Montana in 2017.
Earlier, Turkish President Recep Erdogan said that Ankara did not recognize Crimea as a Russian region and intends to support the Crimean Tatars together with Ukraine.
GSV "Russia - Islamic World"
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Based on materials from RIA Novosti